Calprotectin is a marker of acute inflammatory cell activation. It can be present in plasma and feces. Among them, fecal calprotectin can be used to distinguish inflammatory bowel disease (IBD), mainly including Crohn's disease (CD) and ulcerative colitis (UC), and irritable bowel syndrome (IBS).

Studies have shown that fecal calprotectin examination can be used to evaluate the endoscopic recurrence of CD patients, and its effect is significantly better than that of CRP.